Triple Receptor Activation
Single molecule agonism at GLP-1, GIP, and glucagon receptors — the most comprehensive metabolic mechanism studied to date.
#1 Triple-Agonist Research Peptide
Retatrutide 40mg
Retatrutide 40mg
Injection Pen Kit
The most advanced compound in metabolic research. GLP-1 + GIP + Glucagon triple receptor agonist with 99%+ HPLC-verified purity.
£130
£190
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- 99%+ purity — third-party HPLC + Mass Spec COA
- Free worldwide shipping over £75
- 7–10 day discreet express delivery
- Cold-chain shipping included
- 100% reshipment guarantee
★★★★★ 4.9 / 5 — 847 reviews
The Science
Why Retatrutide is the Most Studied Peptide of 2025
Retatrutide (developmental code LY3437943) is a novel synthetic peptide that simultaneously activates three key metabolic receptors. In Phase 2 trials it produced the largest mean reductions in body weight ever recorded for a single agent.
Glucagon Component
The unique glucagon agonism is what differentiates Retatrutide from Tirzepatide, accelerating energy expenditure in research models.
Phase 2 Data
Eli Lilly Phase 2 published in NEJM (2023) demonstrated up to 24.2% mean body weight reduction at 48 weeks with the highest dose arm.
Research-Grade Synthesis
Manufactured under GMP-equivalent peptide synthesis protocols with full chain-of-custody documentation.
Comparison
Retatrutide vs Tirzepatide vs Semaglutide
| Feature | Retatrutide | Tirzepatide | Semaglutide |
|---|---|---|---|
| Receptor targets | GLP-1 + GIP + Glucagon | GLP-1 + GIP | GLP-1 |
| Generation | Triple agonist (newest) | Dual agonist | Single agonist |
| Weight reduction (Phase 2/3) | ~24.2% | ~22.5% | ~14.9% |
| Energy expenditure boost | Yes (glucagon) | No | No |
| Pen kit dose | 40mg | 40mg | 8mg |
| Research demand 2025 | Highest | High | High |
Product Specifications
What's in the Box
Active compoundRetatrutide (LY3437943)
Total dose40mg per pen
FormatPre-loaded auto-injection pen kit
Purity≥99% (HPLC + Mass Spec)
IncludesPen device, bacteriostatic water, alcohol swabs, COA
Storage2–8°C refrigerated
Shelf life24 months unmixed / 28 days reconstituted
ManufacturerSynedica Labs (in-house GMP-equiv. synthesis)
How It Works
From Order to Lab in 4 Steps
1
Order Online
Secure checkout, crypto and card payments accepted.
2
Discreet Cold-Chain Pack
Shipped within 24h in temperature-controlled packaging.
3
Express Delivery 7–10 Days
Fully tracked. Reships free if customs intercepts.
4
Verify with COA
Match the included Certificate of Analysis batch number.
Ready to Order Retatrutide 40mg?
Premium triple-agonist research peptide. Limited stock — current batch ships from EU warehouse.
Buy Retatrutide — £130
FAQ
Retatrutide — Frequently Asked Questions
What is Retatrutide?
Retatrutide (LY3437943) is a novel triple-agonist research peptide that simultaneously activates GLP-1, GIP, and glucagon receptors — currently the most advanced compound in metabolic research.
How is Retatrutide shipped?
All orders ship discreetly via tracked express courier with cold-chain packaging. Free shipping on orders over £75. UK: 2 business days (Royal Mail). EU: 3 business days (EDP/Chronopost). 100% reshipment guarantee.
What purity is your Retatrutide?
Every batch is third-party tested by HPLC and Mass Spectrometry, certified at ≥99% purity. A unique batch-numbered Certificate of Analysis (COA) is included in every shipment.
Is Retatrutide approved for human use?
No. Retatrutide is currently in clinical trials and is not yet approved by any regulator. Synedica Labs sells this product strictly for in-vitro laboratory research only. Not for human or veterinary consumption.
How do I store the Retatrutide pen?
Store the unmixed pen kit at 2–8°C (standard refrigerator). After reconstitution, use within 28 days kept refrigerated and protected from direct light.
What payment methods do you accept?
We accept major credit/debit cards and cryptocurrency (BTC, ETH, USDT). All payments are processed securely.
Do you ship to my country?
We ship worldwide including USA, UK, EU, Canada, Australia, Brazil, Mexico, Japan, and most of Asia/Africa. Some restricted jurisdictions excluded — see Shipping page.